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These mechanisms raise a theoretical concern: could supratherapeutic doses accelerate unwanted vascular growth or disrupt dopamine signaling enough to produce neuropsychiatric symptoms

Methods Skin specimens from psoriasis patients and healthy donors Skin biopsy specimens were procured from five individuals recently diagnosed with psoriasis and five healthy participants undergoing cosmetic plastic surgery procedures

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10.1097/NEN.0000000000000255 J

Such physiological clearance mediated by the hair-like cilia on the surface of epithelial cells with their fluctuating movement is responsible for the clearing of nasally administered drugs from the nose with a half-life of 21 min (Ozsoy et al., 2009)

Some researchers prefer an alternative method