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In these clinical trials, tirzepatide resulted in HbA1c reduction up to 2.6%, with 7094% of participants achieving HbA1c 6.5% with tirzepatide 15 mg (Table 2, Figure 3)

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Journal of the American Academy of Child & Adolescent Psychiatry, 41, 52-58

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The maintenance in the active state of pyruvate dehydrogenase complex that oxidizes pyruvate to acetyl CoA stimulates oxidative phosphorylation