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In the case of powders, a chemical bond to tartaric acid - L-carnitine-L-tartrate - is used for stabilization

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If the level of colchicine builds up too high, as it might if a usual dose is given to a patient with severe kidney disease, toxicity can occur, such as suppression of the production of blood cells

Other studies have evaluated the synergistic effects of colchicine with vitamin E

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