Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, M.W
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Neither compound has completed dedicated cardiovascular outcomes trials (CVOTs), which are typically required post-approval
It works by disrupting the interaction between the FOXO4 protein and p53, a key regulator of cell survival
Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems