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However, research indicates that its therapeutic effect increases if taken via the orobuccal route (placing the medicine in your mouth and letting it dissolve inside your cheeks)

[DOI] [PubMed] [Google Scholar] 30.Hu D, et al

10.1111/j.1365-2036.2007.03362.x Aliment

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At the microbial level, taxa such as Lactobacillus and Bifidobacterium favour TRP availability for 5-HT synthesis, whereas enrichment of pro-inflammatory Proteobacteria enhances immune-driven IDO activation and KYN production [175], directly linking microbial ecology to mood-relevant neurochemical pathways

Others report no noticeable effects despite weeks of consistent use