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Pan, H., et al.,SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Clinical Significance Optimizing glutathione levels could have profound clinical implications, potentially reducing the incidence and severity of cardiovascular diseases
PDRN acts as a selective adenosine A2A receptor agonist
Induction of both synaptogenesis and synaptic pruning occur through the release of soluble factors and extracellular matrix molecules, such as TGF-Beta1 (83, 84), Hevin, Glypican-4 and -6, Thrombospondin and SPARC
sALS and fALS progression is clinically and pathologically very similar, both characterized by the progressive accumulation of toxic misfolded protein aggregates within cells [76] and the significant loss of MNs [77]