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Giles FJ, Miller CB, Hurd DD, Wingard JR, Fleming TR, Sonis ST, Bradford WZ, Pulliam JG, Anaissie EJ, Beveridge RA, Brunvand MM, Martin PJ, PROMPT-CT Trial Investigators: A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT trial)

This first-in-human study enrolled up to 160 adults across the UK, including healthy volunteers and PD patients

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2-Hydroxyestrone Pathway This is often called the protective pathway

Nature Reviews

The authors reported that the compound restored NAD+ levels in the hearts of the test animals to those of normal mice