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Gradually, we saw tobacco appear in advertisements, commercials, and films

Especially the film noir of the late 1930s and 1940s

Furthermore, RWE studies can prove useful in demonstrating the treatment experience of patients who are often excluded (because of exclusion criteria) or underrepresented in randomized controlled trials [27]

They are sold in a wide range of flavors , such as tobacco, fruit, sweet, or fresh tastes

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