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199,200,201 OCA, an FXR agonist, regulates the expression of transcription factors that reduce BA synthesis and liver steatosis

doi: 10.1016/s0899-9007(00)00327-0 31 Singleton.CMartinP

Collectively, these findings support the interactions of GHK and GHK-Cu complexes with mammalian models as research tools for studying redox regulation, peptide-mediated antioxidant signaling, and oxidative stress modulation

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Methods: Authors used a computer-based gene profiling tool, The Connectivity Map, to identify a number of human genes regulated by GHK, relevant to regulation of cell differentiation, apoptosis and stem cell function