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Lipid peroxidation has been implicated in the pathology of Parkinsons disease and Alzheimers disease, among others [41]

Five of six samples showed high-quality reads and sufficient read numbers (Methods and Extended Data Fig

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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]

doi: 10.1074/jbc.M113.454538 130 Lussey-LepoutreCHollinsheadKELudwigCMenaraMMorinACastro-VegaLJet al