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Moreover, leptin promotes the activation of Kupffer cells, the livers resident macrophages, enhancing the release of inflammatory cytokines such as TNF-, IL-6, and IL-1

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Glutamate dehydrogenase (GLDH) is a mitochondrial protein with less variability than miR-122 and is released into the bloodstream during liver cell damage, making it a promising biomarker for drug-induced liver injury (DILI)

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