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(136) found that IF reduced infarct size, lowered mortality from focal ischemic stroke, and improved brain cell resistance to ischemic injury, involving upregulation of various neuroprotective proteins (neurotrophic factors, chaperones, antioxidants) and downregulation of pro-inflammatory factors (TNF, IL-6, and IL-1)

doi:10.1007/s00213-019-05382-1 112 Rapado-Castro, M., Berk, M., Venugopal, K., Bush, A

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Growth hormone is produced by a gland in our brain called the pituitary gland