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Compared to healthy controls, those with NAFLD who were not obese had statically elevated levels of glutamate, isoleucine and valine, while those with NAFLD who were obese had significantly elevated levels of glutamate, all BCAA, and significantly lower levels of glycine and serine

Immune Modulation

Over time, this may lead to a decrease in the efficiency of the filtration units, known as nephrons

Based on evidence of the dependence of metastatic prostate cancer on ROS [57, 58], this phenomenon could be a prostate cancer-mediated mechanism to maintain ROS levels in the tumor microenvironment, though this will need to be examined further

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While canonical ferroptosis regulation centers on cystine uptake and GPX4-mediated GSH utilization, the endogenous metabolic pathways governing ferroptosis sensitivity in liver tumors remain incompletely understood