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Defective placentation leads to placental hypoxia and reperfusion injury due to ischemia and the resultant OS triggers the release of cytokines and prostaglandins, which results in endothelial cell dysfunction and plays an important role in the development of pre-eclampsia [77, 78]

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50% of the bodys storage of vitamin B12 is kept within the liver, no matter how it is administered, so if the liver is sick, in all likelihood, a person can suffer B12 deficiency