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Not a single-target drug that hammers one pathway and creates side effects elsewhere, but multi-mechanism molecules that can address inflammation, barrier repair, and microbial defense at the same time

doi: 10.1056/NEJM198806233182504 135 XiaoHDairaghiDJPowersJPErtlLSBaumgartTWangYet al

2022 Jan 7;28(1):23-46

2011 Dec;16(6):482

It does so simultaneously at the duodenum and the colon, providing numerous collaterals and branching amid strongly elevated (NOS-2) and decreased aspects (COX-2, VEGF A, NOS-1, NOS-3, nuclear factor-kappa-B-activating protein (Nfkb) gene expression (the mRNA expression studies) [169]

That said, it's important to note that the evidence isn't strong