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cAMP-independent regulation of lipolysis by insulin involves the stimulation of protein phosphatase-1 through phosphorylation of its regulatory subunit (100)
Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)
And in serious research, unknown variables are the enemy
Research suggesting BPC-157 naturally migrates to injury sites supports the value of systemic dosing even for localized problems
It is the difference between knowing what dose you are actually administering and not knowing