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Preclinical studies of Nrp1 including antibody blockades and genetic knockout models have been shown to reduce tumor growth and progression in prostate, lung, and skin cancers [140]

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Nature 545(7653):224228 Incio J et al (2018) Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Tirzepatide is a dual agonist and Semaglutide is a single agonist