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Neoadjuvant pembrolizumab in combination with dabrafenib and trametinib (DTP) for BRAF V600E-mutated anaplastic thyroid cancer (BRAFm-ATC): A multicenter phase 2 trial

In this study, we utilized the acrylamide warhead, renowned for its biocompatibility due to its low non-specific reactivity towards thiol groups, which necessitates an optimal orientation of the acrylamide warhead towards the target cysteines after the initial association step and in the reversibly bound state 3,35

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