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Kefirs microbial metabolism produces numerous bioactive peptides, with 257 identified peptides mainly derived from -casein, among which 16 show ACE-inhibitory, antimicrobial, immunomodulatory, antioxidant, and antithrombotic activities (Ebner et al., 2015)

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Annals of Saudi medicine

J Assist Reprod Genet (2015) 32(4):50920

Together, these findings position NRF2 as the central mediator of melatonin-induced metabolic reprogramming and functional suppression in ILC2s and identify NRF2 as a therapeutically actionable target