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Another approach involves using all-trans retinoic acid (AtRA) to suppress signaling pathways such as TLR4/NF-B, which reduces the expression of iNOS and TNF- in colitis-associated CRC (76)

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Both aim for dual pathway action

10.1016/j.abb.2008.03.008 Arch

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells

Venkateshappa CG, Harish RB, Mythri A, Mahadevan MM, Bharath SK, Shankar