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Whilst vitamin B12 toxicity is exceptionally rare, very high levels from supplements or injections have been associated with skin reactions such as acne-like eruptions

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The causes of this deficiency include poor dietary intake, malabsorption, and pernicious anemia

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Dual-energy X-ray absorptiometry (DEXA) scans, utilized to evaluate bone mineral density and body composition of animal models, may suggest a higher possible fat percentage that may potentially be associated with Ipamorelin