[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Osredkar J., Fabjan T., Kumer K., Jekovec-Vrhovek M., Giebutowicz J., Bobrowska-Korczak B., Avgutin G., Godnov U
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TMAO is mainly derived from gut, where the gut microbiota converts TMA precursors into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver
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Ligand binding to TLRs typically recruits the adaptor protein myeloid differentiation primary response 88 (MyD88), thereby triggering major pro-inflammatory signaling cascades, including the MAPK and nuclear factor kappa B (NF-B) pathways (165, 259)
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