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A range of compounds emitted by CAFs, such as vascular endothelial growth factor A (VEGF-A), is noted to play a role in the stimulation and sustenance of T regulatory (Treg) cells, either directly or indirectly [46]

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This may potentially lead to an increase in hepatocyte growth factor (HGF), a naturally occurring substance in the body that is released at higher levels to aid in the recovery from synapse damage

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It also stimulates the activation of a unique population of T cells called T follicular helper (TFH) cells, which promote B cell differentiation into antibody-secreting plasma cells (9)

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