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doi: 10.1038/s41420-023-01613-9 47 BockFJTaitSWG

Blood advances , 6 9, 2897-2907 Vogel, Mona

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rxlist.com (Enlon ) Keywords Organophosphate Cholinesterase Inhibitors Echothiophate Trade Name: Phospholine Iodide Drug Class: Anticholinesterase ( Organophosphate ) Mechanism of Action: for topical use to enhance the effect of endogenously liberated acetylcholine in the iris, ciliary muscle, and other parasympathetically innervated structures of the eye Irreversible long-acting cholinesterase inhibitor It causes miosis, increases the outflow of aqueous humor, causes a fall in intraocular pressure, and potentiation of accommodation Indications: Historically used for treatment of glaucoma but currently very rarely used, and frequently regarded as obsolete for the routine treatment of glaucoma (Figure 1)

Standard daily dose: 2 mg (2000 mcg) once daily subcutaneously (FDA-approved protocol)