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However, it validates longstanding principles of analgesia (specifically, the analgesic ladder)

Individuals should be particularly cautious when combining clonidine with other medications, such as sedatives or opioids, as these combinations can amplify the sedative effects and increase the risk of respiratory depression

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Avoid strenuous exercise and alcohol for 24 to 48 hours

Some researchers report strong effects even at 20 mcg daily, while others require higher doses for noticeable results