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It is important to note that B12 levels should ideally be measured before commencing replacement therapy, as supplementation rapidly normalises biochemical markers, potentially obscuring the diagnosis

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That matters because, unlike most peptides, a small molecule can be studied orally as well as by injection it has no peptide bonds for digestive enzymes to cleave

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248 Curcumin (Cur) is a natural polyphenolic compound derived from the rhizome of plants such as Curcuma longa L