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Higher doses of the seed extract (500, 1,000, and 2,000 mg/kg) resulted in death rates of 20%, 60%, and 80%, respectively

Considering the amino acid transport mechanism of system Xc , a high extracellular Glu level will suppress this transport to a certain extent and induce ferroptosis, which may also be one of the reasons why Glu accumulation in the nervous system may cause damage (Dixon et al

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doi: 10.1371/journal.pone.0167295 288 NamiS.MohammadiR.VakiliM.KhezripourK.MirzaeiH.MorovatiH.et al

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