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For this reason the effective size of a ligand is sometimes rated in terms of either a cone angle of space they are estimated to occupy around the metal (called the Tolman cone angle, it is commonly used to evaluate phosphines' steric bulk) or the in terms of the percentage of the metal's coordination sphere the ligand occupies (called the percent buried volume, it is used to estimate the steric impact of N -heterocyclic carbenes)

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Han, et al

J., Lu, X

Both play critical roles in healthy aging but in different ways

DSIP + Selank Combines stress-response modulation with anxiolytic neuropeptide signaling