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The magnitude of blood pressure reduction is clinically meaningful and exceeds that typically achieved with single antihypertensive medications

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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

2021, doi:10.1016/j.amsu.2021.102917 Sun, Xiaojin et al

Because compounding pharmacies typically require a doctors prescription, patients generally access these drugs under at least some degree of medical supervision