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Factors associated with impaired cerebrovascular reactivity and neurovascular coupling include cerebral microvascular dysfunction, insulin-like growth factor 1 (IGF-1) deficiency, and oxidative stress-related inhibition of neuronal and astrocytic vasodilators (Phillips et al., 2016

The study included 151 patients with CFS, who were randomly divided into a rituximab (n=77) and a placebo control group (n=74)

Consider timing : Maybe wait to start protocol until after trip