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Changes in brain insulin metabolism and insulin resistance are associated with several CNS disorders such as Alzheimers disease (AD), depression [71,72,73], autism [74], schizophrenia [75], Huntingtons disease [76], Parkinsons disease (PD) [77], etc

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Calibration was performed using standard concentrations of vitamin B 12 (20-160 g/ml) in the presence of constant concentrations of vitamin B 1 and B 6 (each 0.02 mg/ml)

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