Clinical Significance of Folate Deficiency Folate deficiency results in complications nearly identical to those described for vitamin B12 deficiency
Neuroscientist 11 (5), 417440 (2005)
(2022) found that serum TSH levels were significantly higher in winter and lower in summer, while free T4 showed an opposite trend, with slightly higher values in summer
It may also provide a logical explanation for why UA can function as an antioxidant to block the effects of exogenous peroxynitrite to uncouple endothelial NO synthase[18] yet in the presence of high concentrations of UA favor the reduction of intracellular NO levels.[16] It also provides an explanation for why UA infusions into healthy individuals (likely with good intracellular glutathione stores) do not cause endothelial dysfunction acutely.[25] Finally, it could explain the recent report[26] that allopurinol improves endothelial function by blocking oxidative stress rather than by lowering serum UA concentrations
References Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L
On Thursday, the FDA kicked off a two-day meeting to assess the safety and efficacy of lab-made peptides, which some supporters claim can build muscle, treat injuries and look younger
