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Poly ADP-ribose polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death

Although contrary to the notion that G6PD-d largely limits proliferative capacity, Varghese et al

Chang PV, Bertozzi CR

NMN (Nicotinamide Mononucleotide) is a precursor to NAD+, a molecule that fuels cellular repair

Minimal downtime is required

The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)