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Notably, compounding walnut peptide with ginseng saponin to feed senescence-accelerated mice (SAM) revealed that walnut peptide significantly increased the serum levels of antioxidant enzymes and reduced A and p-tau in the hippocampus through activation of the brain-derived neurotrophic factor (BDNF)/TrkB-dependent PI3K/Akt signalling pathway, significantly improving the memory of rats with neurodegenerative disease capacity (118)

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In contrast, the dimeric macrocycles strongly promoted closure of the scratched area with effects comparable to hHGF

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