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By eliminating acetyl groups from the lysine residues of proteins, HDACs not only inhibit gene transcription, but also cause alternative post-translational lysine modifications including methylation, ubiquitination, and sumoylation [36]

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Published research includes effects on collagen and extracellular matrix biology, partly via copper-dependent lysyl oxidase

Standard metformin monitoring (HbA1c every 3 to 6 months, annual renal function, annual B12 level) is sufficient [4]