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Biological therapies, especially anti-TNF therapy are effective treatments, but the primary lack of response to TNF inhibitors or the secondary loss of response among some patients requires the search for new therapeutic solutions [121,122,123]

However, under therapy-induced stress, cancer cells and non-neoplastic stromal cells mobilize survival signals that nurture the residual disease until minority drug-resistant clones emerge to lead the outgrowth of a drug-resistant tumor

D.PangP.ZhouX

Apr 1984;4(2 Pt 2):S58-70

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