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Ferroptosis is a form of cell death dependent on reactive oxygen species (ROS) and is characterized by two main biochemical features: lipid peroxidation and iron accumulation 8

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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

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