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Cytochrome P450 (CYP) oxidizes drugs using O 2 and cofactors like NADPH and is highly versatile in modifying multiple different substances and drugs, but it varies across species

TGF- is mediated by the transcription factor mothers against decapentaplegic homology (SMAD) that bind SMAD binding element (SBE) of target genes, regulating their expression [97]

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Prolonged heroin use leads to receptor downregulation and desensitization mediated by G protein-coupled receptor kinase and arrestin (Saurer et al., 2009)

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