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Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M (2016) A glycine-insulin autocrine feedback loop enhances insulin secretion from human -cells and is impaired in type 2 diabetes.

C57BL/6J wild-type (WT) mice were purchased from Jackson Laboratory (Bar Harbor, ME)

37 KochA.KangH.-G.SteinbrennerJ.DempseyD

( i - l ) Daily energy intake, ( m - p ) daily TEE, and ( q - t ) respiratory exchange ratio (RER)

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As seen in the preclinical results, GSH was at a 4-fold reduction in theT2DM group when compared to the healthy group, therefore supplementing with L-GSH can maintain GSH levels, decrease the levels of oxidized GSH, decrease the levels of the proinflammatory cytokine IL-6 and other oxidative stress markers in individuals with diabetes