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I.et al (2022a)

The cellular concentration of GSH, therefore, is regulated by a complex process of precursor amino acid transport across cell membranes, intracellular synthesizing enzymes, feedback regulation, and intracellular GSH complexing via conjugation of GSH with a variety of electrophilic compounds through GSH transferase reactions

Therefore, extrapolation from in vitro potency to clinical efficacy must be interpreted cautiously