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flank: p = 0.6482) (k) levels in mice bearing orthotopic (n = 11), flank (n = 4), or no Gclc WT tumors (n = 8)

Long-term over-exposure is linked to a higher risk of breast cancer, so more estrogen means bigger breasts is not always healthy

Surface modification facilitates the exploitation of endogenous transport mechanisms, thereby enabling dendrimer-mediated traversal of the BBB and enhancing the CNS delivery efficiency (115)

NACs antioxidant role is partly indirect through glutathione, and partly direct through its own free-radical scavenging and redox effects

Acknowledgments The authors are grateful for the kind support provided by John Poulton, Susan Poulton, and Tabitha J

Pro-inflammatory cytokines represented by IL-1, IL-6, TNF- , and IFN can activate IDO, while anti-inflammatory cytokines such as IL-4 can down-regulate the enzyme