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A 2014 meta-analysis (pooled analysis of published data) showed fumaric acid treatment was as effective as methotrexate for the treatment of psoriasis (Schmitt 2014)

Response differences are based on baseline metabolic characteristics, diet, and comorbid disease

Third, it raises questions about the optimal duration of therapy and whether intermittent dosing might maintain benefits

Consistency in measurement method matters more than absolute accuracy

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Discussion We have attempted to illustrate likely risks associated with major surgery and extended possi- ble analgesic use in patients [2] including poor initial healing, lesions occurring in other organs during the most critical early period, COX-blockade, and additional NOS-blockade, in a rat model permitting acute evaluation within 24 hours