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Less studied is the observation that fibroblasts from AD patients show altered expression of EAAT1 amino acid transporter, with the degree of alteration correlating with dementia severity [555]

Importantly, this regulation cascade can be exploited by targeting YBX1 to block AMPK protein synthesis and targeting GLUT1 to induce energy stress, which synergistically blunts tumor growth in vivo

The juxta membrane domain contains the Y1003 residue which binds to proteins such as c-Cbl, the protein responsible for ubiquitination of c-MET thereby its activation

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