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The altered dynamic properties of the mitochondrial membrane, which affects GSH transport, could also be restored by A2C administration, as demonstrated in isolated mitochondria from long-term ethanol-fed rats [68]

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When GSH is depleted, glutathione reductase 4 (GPX4) is inactivated, resulting in an oxidation-antioxidant imbalance [13]

Darmaun D, Smith SD, Sweeten S, Hartman BK, Welch S, Mauras N

The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin

Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: the MOUSEION-02 study