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Glutathione disulfide reductase (GSR) can recycle oxidized glutathione using electrons sourced from reduced NADPH to restore glutathione ( Figure 1 ) (52)

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Along with the breakdown of antioxidant defenses, there can be dramatic skin membrane lipid peroxidation, triggering ferroptosis, a skin cell death

In the future, functional studies regarding certain metabolites should be conducted in vitro and in EAE models to provide stronger evidence that altered metabolic pathways coordinate the immune system to maintain the immunoinflammatory state of MS