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For everything else, injection is the clinically validated route

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The only large study of healthy adults examining B12 supplement safety, using NHANES data, found no association between B12 supplementation and increased mortality at any dose, including 1,000 g/day or more (Wolffenbuttel, 2020)

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They should remain separated from the main dosing protocol because the FDA review specifically flagged the absence of published human exposure data for subcutaneous, transdermal, and intranasal routes

Additionally, the portion of the small intestine responsible for absorbing the vitamin may be bypassed or reduced, further impacting absorption