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This modification promotes albumin binding and extends the half-life to approximately five days, enabling once-weekly dosing

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EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: a case report

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PMID:24752591

The effort needed to optimize these regimens can be experienced as aversive, promote frustration, and generate a desire to avoid such effort, aligning with a region of the brain called the anterior midcingulate cortex, as described by Lisa Feldman Barrett and colleagues