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Given the brains unique susceptibility to proteotoxic stress, owing to its post-mitotic neuronal population, high metabolic demand, and reliance on precise proteome regulation, UPS integrity is indispensable for neuronal survival

Kruiswijk F, Labuschagne CF, Vousden KH (2015) p53 in survival, death and metabolic health: a lifeguard with a licence to kill

MitoQ 10 is the most studied of them all

Chada S, Mhashilkar A, McKenzie T, Liu Y, Swisher SG , Hunt K

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Disrupted FAO and Level of NAD + in AKI Several studies have shown that a low level of NAD + and compromised mitochondrial function leads to briefly disrupted fatty acid oxidation (FAO) during AKI [107,135,136,137]