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Next, the NF-kB pathway was examined

Mitochondrial unfolded protein response (UPRmt) helps upregulate mitochondrial function and frequency of miniature excitatory postsynaptic currents when exposed to general anesthetics ( Autophagy may be a double-edged sword Autophagy is a process of natural degradation that can help maintain metabolic stability (Xu et al., 2018

Oxidative damage has been implicated to be a major factor in the decline in physiologic function that occurs during the aging process 1,2

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However, more recent studies and meta-analyses with larger sample sizes suggest the opposite

In a systematic review and meta-analysis, depression was associated with significantly increased oxidative stress as measured by biomarkers of oxidative DNA damage (8-OHdG) and lipid peroxidation (F-isoprostanes) compared to non-depressed controls (3537)