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In the absence of sleep deprivation, injection of GHRH in early sleep did not modify SW sleep but increased REM sleep

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Therefore, a ghrelin-GH-IGF-1 axis is activated by chronic stress, enhancing fear memory via amygdala neurons

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The compound also downregulates microphthalmia-associated transcription factor (MITF) expression, which decreases both tyrosinase expression and melanocyte proliferation

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Zhu Y., Yang J